open magazine

Publications

Working Group Cellular Protein Homeostasis

2025

Kurpa O and Amponsah PS (2025). How do genome abnormalities impact mitochondrial homeostasis? BIOspektrum 31, 23-25. doi: 10.1007/s12268-025-2372-5

Amponsah PS, and Storchova Z (2025). The proteostasis burden of aneuploidy. Biol Chem. 406, 331-343. doi: 10.1515/hsz-2024-0163

Amponsah PS, Bökenkamp J, Kurpa O, Lenhard S, Myronova A, Velazquez DOV, Hirschelmann C, Behrends C, Herrmann JM, Räschle M, and Storchova Z (2025). Aneuploidy-induced proteostasis disruption impairs mitochondrial functions and mediates aggregation of mitochondrial precursor proteins through SQSTM1/p62. Nat Commun 16, 5328. doi: 10.1038/s41467-025-60857-4

Zimmermann J, Lang L, Calabrese G, Laporte H, Amponsah PS, Michalk C, Sukmann T, Oestreicher J, Tursch A, Peker E, Owusu TNE, Weith M, Roma LP, Deponte M, Riemer J, Morgan B (2025). Tsa1 is the dominant peroxide scavenger and a source of H₂O₂-dependent GSSG production in yeast. Free Radic. Biol. Med. 226, 408-420. doi: 10.1016/j.freeradbiomed.2024.11.004

 

2022

Yahya G, Menges P, Amponsah PS, Ngandiri DA, Schulz D, Wallek A, Kulak N, Mann M, Cramer P, Savage V, Räschle M, and Storchova Z (2022). Sublinear scaling of the cellular proteome with ploidy. Nat Commun: 13, 6182. doi: 10.1038/s41467-022-33904-7

 

2021

Amponsah PS, Yahya G, Zimmermann J, Mai M, Mergel S, Mühlhaus T, Storchova Z, and Morgan B (2021). Peroxiredoxins couple metabolism and cell division in an ultradian cycle.

Nat Chem Biol 17, 477-484. doi: 10.1038/s41589-020-00728-9

 

2019

Calabrese G, Peker E, Amponsah PS, Hoehne MN, Riemer T, Mai M, Deponte M, Morgan B, Riemer J (2019). Hyperoxidation of mitochondrial peroxiredoxin limits H₂O₂-induced cell death in yeast. EMBO 38, e101552. doi: 10.15252/embj.2019101552

 

2017

Amponsah PS, Fan P, Bauer N, Zhao Z, Gladkich J, Fellenberg J, Herr I (2017). microRNA-210 overexpression inhibits tumor growth and potentially reverses gemcitabine resistance in pancreatic cancer. Cancer Lett. 388, 107-117. doi: 10.1016/j.canlet.2016.11.035

2016

Morgan B, Van Laer K, Owusu TN, Ezerina D, Pastor-Flores D, Amponsah PS, Tursch A, Dick TP (2016). Real-time monitoring of basal H₂O₂ levels with peroxiredoxin-based probes. Nat. Chem. Biol. 12, 437-443. doi: 10.1038/nchembio.2067

Fan P, Liu L, Yin Y, Zhao Z, Zhang Y, Amponsah PS, Xiao X, Bauer N, Abukiwan A, Nwaeburu CC, Gladkich J, Gao C, Schemmer P, Gross W, Herr I (2016). MicroRNA-101-3p reverses gemcitabine resistance by inhibition of ribonucleotide reductase M1 in pancreatic cancer. Cancer Lett. 373, 130-137. doi: 10.1016/j.canlet.2016.01.038

Amponsah PS (2016). Cellular redox - living chemistry. Science in School 36: 15-17. scienceinschool.org/article/2016/cellular-redox-living-chemistry/