Prof. Dr. Stefan Kins
Building 13, Room 113.1
E-mail: s.kins(at)rptu.de
Phone +49 (631) 205-2106
Office hours:
by appointment
Research focus
Our research focuses on the molecular basis of Alzheimer's disease (AD).
The amyloid precursor protein (APP) plays a central role in Alzheimer's disease (AD). We are investigating both its disease-promoting and its normal functions in the healthy brain. To better understand the physiological function of APP, we analyze its interaction partners such as FE65 and perform genetic studies on APP knockout cells.
A particular focus of our research is on the intracellular transport of APP, as this is crucial for its function and possibly also for the development of Alzheimer's disease. On the other hand, we are interested in the function of APP as a cell adhesion molecule with a particular focus on its function at the synapse and its interaction with the cytoskeleton.
Curriculum Vitae
Academic career
- since 2008
University Professor (W2) for Human Biology and Human Genetics at RPTU Kaiserslautern-Landau
- 2007-2008
Independent group leader at the Center for Molecular Biology, University of Heidelberg
- 2003-2007
Project manager at the Center for Molecular Biology at Heidelberg University
- 2001-2003
Research assistant in the research group of Prof. Dr. K. Beyreuther at the Center for Molecular Biology at Heidelberg University
- 1999-2001
Post-doc at the Department of Adult Psychiatry and Psychotherapy at the University of Zurich
- 1999
Dr. phil. nat. (PhD) in Biochemistry (grade: summa cum laude) from the University of Frankfurt, Max Planck Institute for Brain Research
- 1996
Diploma in Biology, University of Frankfurt
Functions
- since 2023
Dean of the Biology Department at RPTU Kaiserslautern-Landau
- 2020-2022
Vice Dean of the Biology Department at the Technical University of Kaiserslautern
- since 2019
Co-Speaker NeurodegX
- since 2018
Co-Speaker GBM Study Group Molecular Neurobiology
- "
Member of the scientific advisory board of Alzheimer's Research Initiative
- "
Member of the editorial board of Cells magazine
Selected publications
August A, Hartmann S, Schilling S, Müller-Renno C, Begic T, Pierik A, Ziegler C and Kins S (2024) Zinc and copper effect mechanical cell adhesion properties of the amyloid precursor protein Biological Chemistry, 405 (11-12): 701-710. DOI: 10.1515/hsz-2024-0054
Schilling S, August A, Meleux M, Conradt C, Tremmel LM, Teigler S, Adam V, Müller UC, Koo EH, Kins S*, Eggert S* (2023) APP family member dimeric complexes are formed predominantly in synaptic compartments. Cell & Bioscience 13 (1), 1-24 *contributed equally. DOI:10.1186/s13578-023-01092-6
