Brief Curriculum Vitae Prof. Dr. Stefan Kins

Academic positions and appointments:

 

Since 2008:   Univ.-Professor (W2) for Human Biology and Human Genetics at the Technical University of Kaiserslautern

2007-2008:   Independent group leader at the ZMBH, University of Heidelberg

2003-2007:   Project leader at the ZMBH, University of Heidelberg

2001-2003:   Assistant in the research group of Prof. Dr. K. Beyreuther at the Centre for molecular biology (ZMBH), University of Heidelberg

1999-2001:   Postdoc, Department for Psychiatric Research, University of Zürich

1999:   Dr. phil.nat. (PhD) in Biochemistry (grade: summa cum laude) at the University of Frankfurt; Max Planck Institute for brain research

1996:   Diploma (M.Sc.) in Biology, University of Frankfurt

 

Since 2023: Dean of the department of Biology at the RPTU University Kaiserslautern-Landau 

2020-2022: Vice-Dean of the Department for Biology at the TU Kaiserslautern

Since 2019: Co-speaker NeurodegX

Since 2018: Co-speaker GBM Study Group

 


Selected Publications:

August A, Hartmann S, Schilling S, Müller-Renno C, Begic T, Pierik A, Ziegler C and Kins S (2024) Zinc and copper effect mechanical cell adhesion properties of the amyloid precursor protein Biological Chemistry, 405 (11-12): 701-710

Schilling S, August A, Meleux M, Conradt C, Tremmel LM, Teigler S, Adam V, Müller UC, Koo EH, Kins S*, Eggert S* (2023) APP family member dimeric complexes are formed predominantly in synaptic compartments. Cell & Bioscience 13 (1), 1-24 *contributed equally

Eggert S, Gruebl T, Rajender R, Rupp C, Sander B, Heesch A, Zimmermann M, Hoepfner S, Zentgraf H,   Kins S (2020) The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif. Cell Mol Life Sci. 77:5223-5242 

 August A, Schmidt N, Klingler J, Baumkötter F, Lechner M, Klement J, Eggert S, Vargas C, Wild K, Keller S, Kins S (2019) Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways. J Neurochem 151:626-641

 Eggert S, Gonzalez AC, Thomas C, Schilling S, Schwarz SM, Tischer C, Adam V, Strecker P, Schmidt V, Willnow TE, Hermey G, Pietrzik CU, Koo EH, Kins S (2018) Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.Cell Mol Life Sci. 75: 301-22. 

Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S*, Eggert S* (2017) APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. J Neurosci 37: 5345-5365. *contributed equally

Strecker P, Ludewig S, Rust M, Mundinger TA, Görlich A, Krächan EG, Mehrfeld C, Herz J, Korte M, Guénette SY and Kins S (2016) FE65 and FE65L1 share common synaptic functions and genetically interact with the APP Family in neuromuscular junction formation. Sci Reports 6: 25652.

Baumkötter F, Schmidt N, Vargas C, Schilling S, Weber R, Wagner K, Fiedler S, Klug W, Radzimanowski J, Nickolaus S, Keller S, Eggert S, Wild K and Kins S (2014) Amyloid Precursor Protein dimerization and synaptogenic function depend on copper binding to the growth factor like domain. J Neurosci 34: 11159-72.

Szodorai A, Kuan YH, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S (2009) APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. J Neurosci 29: 14534-14544.

Soba P, Eggert S, Zentgraf H, Kreger S, Löwer A, Merdes G, Paro R, Masters CL, Müller U, Kins S*, Beyreuther K* (2005) Cell interactions are promoted by trans-dimerization of APP family members, arranged as homo- or hetero-complexes in synaptic membranes. EMBO J 24: 3624-36. *contributed equally