Gerhard Erkel

Selected Publications:

Felix S, Sandjo LP, Opatz T, Erkel G (2014) Anti-inflammatory drimane sesquiterpene lactones from an Aspergillus species. Bioorg Med Chem 22:2912-2918.

Henke J, Erkel G, Brochhausen C, Kleinert H, Schwarting A, Menke J, Pautz A (2014) The fungal lactone oxacylododecindione is a potential new therapeutic substance in the treatment of lupus-associated kidney disease. Kidney Int doi:10.1038/ki.2014.109.

Rudolph K, Serwe A and Erkel G (2013) Inhibition of TGF-beta signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone. Cytokine 61:285-296.

Schmidt N, Art J, Forsch I, Werner A, Erkel G, Jung M, Horke S, Kleinert H and Pautz A (2012) The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis. J Pharmacol Exp Ther 343:106-114.

Serwe A, Rudolph K, Anke T, Erkel G (2012) Inhibition of TGF-β signaling, vasculogenic mimicry and proinflammatory gene expression by isoxanthohumol. Invest New Drugs 30:898-915.

Schmidt N, Pautz A, Art J, Rauschkolb P, Jung M, Erkel G, Goldring MB and Kleinert H (2010) Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes. Biochem Pharmacol 79:722-732.

Serwe A, Anke T, Erkel G (2009) The fungal secondary metabolite trichodimerol inhibits TGF-β dependent cellular effects and tube formation of MDA-MB-231 cells. Invest New Drugs 27:491-502.

Jung M, Triebel S, Anke T, Richling E, Erkel G (2009) Influence of apple polyphenols on inflammatory gene expression. Mol Nutr Food Res 53: 1263-1280.

Elzner S, Schmidt D, Schollmeyer D, Erkel G, Anke T, Kleinert H, Forstermann U, Kunz H (2008) Inhibitors of inducible NO synthase expression: total synthesis of (S)-curvularin and its ring homologues. ChemMedChem 36:924-939.

Erkel G, Wisser G, Anke T (2007) Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells. Int Immunopharmacol 7:612-624.

Erkel G, Belahmer H, Serwe A, Anke T, Kunz H, Kolshorn, H, Liermann, J, Opatz T. (2008). Oxacylododecindione, a novel Inhibitor of IL-4 signaling from Exserohilum rostratum. J. Antibiotics 61, 285-290.