Publikationen
Arbeitsgruppe Humanbiologie
Kiss E, Kirsch J, Kuhse J, Kins S (2025) Is the Activation of the Postsynaptic Ligand Gated Glycine- or GABAA Receptors Essential for the Receptor Clustering at Inhibitory Synapses? Biomedicines 13, 1905. doi: 10.3390/biomedicines13081905.
Ebding J, Mazzone F, Kins S, Pielage J, Maritzen T (2025) How neurons cope with oxidative stress. Biol Chem, 406(5-7),219. doi: 10.1515/hsz-2024-0146.
August A, Hartmann S, Schilling S, Müller-Renno C, Begic T, Pierik A, Ziegler C and Kins S (2025) Zinc and copper effect mechanical cell adhesion properties of the amyloid precursor protein Biological Chemistry, 405 (11-12): 701-710
König S, Bakuradze T, Jesser S, Sreeja HA, Carlsson MJ, Fahrer J, Kins S, Richling E (2024) Influence of Bilberry Extract on Neuronal Cell Toxicity. Biology 13, 376. doi: 10.3390/biology13060376
Kiss E, Kins S, Gorgas K, Venczel Szakács KH, Kirsch J, Kuhse J (2024) Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer’s Disease. International Journal of Molecular Sciences 25, 4165. doi: 10.3390/ijms25084165.
König S, Schmidt N, Bechberger K, Morris S, Priego M, Zaky H, Song Y, Pielage J, Brunholz S, Brady ST, Kins S*, Morfini G* (2023) Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport. Cells 2023, 12, 2403. doi: 10.3390/cells12192403. *contributed equally
Schilling S, August A, Meleux M, Conradt C, Tremmel LM, Teigler S, Adam V, Müller UC, Koo EH, Kins S*, Eggert S* (2023) APP family member dimeric complexes are formed predominantly in synaptic compartments. Cell & Bioscience 13 (1), 1-24 *contributed equally.
Schilling S, Pradhan A, Heesch A, Helbig A, Blennow K, Koch C, Bertgen L, Koo EH, Brinkmalm G, Zetterberg H, Kins S*, Eggert S* (2023) Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity. Acta Neuropathologica Communications 11 (1), 87. doi: 10.1186/s40478-023-01577-y. *contributed equally
Morfini G and Kins S (2023) Kinase/phosphatase signaling and axonal function in health and disease Frontiers in Cellular Neuroscience 17, 1172836. doi: 10.3389/fncel.2023.1172836.
Rajão‐Saraiva J, Dunot J, Ribera A, Temido‐Ferreira M, Coelho JE, König S, Moreno S, Enguita FJ, Willem M, Kins S, Marie H, Lopes LV, Pousinha PA (2023) Age‐dependent NMDA receptor function is regulated by the amyloid precursor protein. Aging Cell 22 (3), e13778. doi: 10.1111/acel.13778.
Kuhse J, Groeneweg F, Kins S, Gorgas K, Nawrotzki R, Kirsch J, Kiss E (2023) Loss of extrasynaptic inhibitory Glycine receptors in the Hippocampus of an AD mouse model is restored by treatment with artesunate. Int J Mol Sci 24 (5), 4623. doi: 10.3390/ijms24054623.
Mushtaq Z, Aavula K, Lasser DA, Kieweg ID, Lion LM, Kins S, Pielage J (2022) Madm/NRBP1 mediates synaptic maintenance and neurodegeneration-induced presynaptic homeostatic potentiation Cell Reports 41 (9). doi: 10.1016/j.celrep.2022.111710
Glueck D, Grethen A, Das M, Mmeka OP, Patallo EP, Meister A, Rajender R, Kins S, Räschle M, Victor J, Chu C, Etzkorn M, Köck Z, Bernhard F, Babalola JO, Vargas C, Keller S (2022). Electroneutral Polymer Nanodiscs Enable Interference‐Free Probing of Membrane Proteins in a Lipid‐Bilayer Environment Small 18 (47), 2202492. doi: 10.1002/smll.202202492
Klein M, Kaleem A, Oetjen S, Wünkhaus D, Binkle L, Schilling S, Gjorgjieva M, Scholz R, Gruber-Schoffnegger D, Storch S, Kins S, Drewes G, Hoffmeister-Ullerich S, Kuhl D, Hermey G (2022) Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome system. Autophagy 18 (9), 2068-2085. doi: 10.1080/15548627.2021.2016232.
S Kins, KH Schäfer, K Endres (2022) Drug development for neurodegenerative diseases, Biological Chemistry 403 (1), 1. doi: 10.1515/hsz-2021-0413
Eggert S, Kins S, Endres K, Brigadski T (2022) Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of Alzheimer’s disease. Biological Chemistry 403 (1), 43-71. doi: 10.1515/hsz-2021-0330.
Nguyen VTT, König S, Eggert S, Endres K, Kins S (2022) The role of mycotoxins in neurodegenerative diseases: current state of the art and future perspectives of research. Biological Chemistry 403 (1), 3-26. doi: 10.1515/hsz-2021-0214.
Augustin V and Kins S (2021) Fe65: A Scaffolding Protein of Actin Regulators. Cells 10, 159
Kiss E, Kins S, Gorgas K, Orlik M, Fischer C, Endres K, Schlicksupp A, Kirsch J, Kuhse J (2022) Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABAAR density. Biol Chem403 (1), 73-87. doi: 10.1515/hsz-2021-0153.
Witthohn M, Strieth D, Eggert S, Kins S, Ulber R, Muffler K (2021) Heterologous production of a cyanobacterial bacteriocin with potent antibacterial activity, Current Research in Biotechnology 3, 281-287
Kiss E, Kins S, Zöller Y, Schilling S, Gorgas K, Groß D, Schlicksupp A, Rosner R, Kirsch J, Kuhse J. (2021) Artesunate restores the levels of inhibitory synapse proteins and reduces amyloid-β and C-terminal fragments (CTFs) of the amyloid precursor protein in an AD-mouse model. Mol Cell Neurosci 113:103624
Eggert S, Gruebl T, Rajender R, Rupp C, Sander B, Heesch A, Zimmermann M, Hoepfner S, Zentgraf H, Kins S (2020) The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif. Cell Mol Life Sci. 77:5223-5242
August A, Schmidt N, Klingler J, Baumkötter F, Lechner M, Klement J, Eggert S, Vargas C, Wild K, Keller S, Kins S (2019) Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways. J Neurochem 151:626-641
Eggert S, Gonzalez AC, Thomas C, Schilling S, Schwarz SM, Tischer C, Adam V, Strecker P, Schmidt V, Willnow TE, Hermey G, Pietrzik CU, Koo EH, Kins S (2018) Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.Cell Mol Life Sci. 75: 301-22
Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S*, Eggert S* (2017) APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. J Neurosci 37: 5345-5365. *contributed equally
Strecker P, Ludewig S, Rust M, Mundinger TA, Görlich A, Krächan EG, Mehrfeld C, Herz J, Korte M, Guénette SY and Kins S (2016) FE65 and FE65L1 share common synaptic functions and genetically interact with the APP Family in neuromuscular junction formation. Sci Reports 6: 25652.
Baumkötter F, Schmidt N, Vargas C, Schilling S, Weber R, Wagner K, Fiedler S, Klug W, Radzimanowski J, Nickolaus S, Keller S, Eggert S, Wild K and Kins S (2014) Amyloid Precursor Protein dimerization and synaptogenic function depend on copper binding to the growth factor like domain. J Neurosci 34: 11159-72.
Szodorai A, Kuan YH, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S (2009) APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. J Neurosci 29: 14534-14544.
Soba P, Eggert S, Zentgraf H, Kreger S, Löwer A, Merdes G, Paro R, Masters CL, Müller U, Kins S*, Beyreuther K* (2005) Cell interactions are promoted by trans-dimerization of APP family members, arranged as homo- or hetero-complexes in synaptic membranes. EMBO J 24: 3624-36. *contributed equally