Eva Kiss, Stefan Kins, Karin Gorgas, Kinga Hajnal, Venczel Szakács, Joachim Kirsch, Jochen Kuhse, Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer's Disease, International Journal of Molecular Sciences, Review

Svenja König, Tamara Bakuradze , Sandy Jesser, Harshitha Ashoka Sreeja , Max J. Carlsson, Jörg Fahrer, Stefan Kins,Elke Richling, Influence of Bilberry Extract on Neuronal Cell Toxicity, MDPI

Jochen Kuhse, Femke Groeneweg, Stefan Kins, Karin Gorgas, Ralph Nawrotzki, Joachim Kirsch, Eva Kiss Loss of Extrasynaptic Inhibitory Glycine Receptors in the Hippocampus of an AD Mouse Model Is Restored by Treatment with Artesunate, Int J Mol Sci. doi.org/10.3390/ijms24054623

Svenja König, Nadine Schmidt, Karin Bechberger, Sarah Morris, Mercedes Priego, Hannah Zaky, Yuyu Song, Jan Pielage, Silke Brunholz,  Scott T. Brady, Stefan Kins, Gerado Morfini Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport, Cells doi: 10.3390/cells12192403.

Gerado Morfini, Stefan Kins, Kinase/phosphatase signaling and axonal function in health and disease, Frontiers doi: 10.3389/fncel.2023.1172836

Sandra Schilling, Ajay Pradhan, Amelie Heesch, Andrea Helbig, Kaj Blennow, christian Koch, Lea Bertgen, Edward H Koo, Gunnar Brinkmalm, Henrik Zetterberg,  Stefan Kins, Simone Eggert Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity, Acta Neuropathologica Communications doi:10.21203/rs.3.rs-2293469/v1

Glück D,  Grethe A, Das M, Mmeka OP, Patallo EP, Meister A, Rajender R, Kins S, Räschle M, Victor J, Chu C, Etzkorn M, Köck Z, Bernhard F, Babalola JO, Vargas c, Keller S. Electroneutral Polymer Nanodiscs Enable Interference-Free Probing of Membrane Proteins in a Lipid-Bilayer Environment. Small 13. Oktober 2022, doi.org/10.1002/smll.202202492

Mushtaq Z ,Aavula K, Lasser D A, Kieweg I D, Lion L M, Kins S, Pielage J. Madm/NRBP1 mediates synaptic maintenance and neurodegeneration-induced presynaptic homeostatic potentiation. CVell Reports 29.November 2022, doi.org/10.1016/j.celrep.2022.111710

Schilling S, August A, Meleux M, Conradt C, Tremmel L, Teigler S, Adam V, Koo EH, Kins S, Eggert S. APP family member dimeric complexes are formed predominantly in synaptic compartments. bioRxib 16.September 2022, doi.org/10.1101/2022.09.13.507759

Witthohn M, Strieth D, Eggert S, Kins S, Ulber R, Muffler K. Heterologous production of a cyanobacterial bacteriocin with potent antibacterial activity Current Research in Biotechnology, Elsevier 16. November 2021, doi.org/10.1016/j.crbiot.2021.10.002

Klein M, Kaleem A, Oetjen S, Wünkhaus D, Binkle L, Schilling S, Gjorgjieva M, Scholz R, Gruber-Schoffnegger D, Storch S, Kins S, Drewes G, Hoffmeister-Ullerich S, Kuhl D, Hermey G.  Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome system. Autophagy 2021 Dec 29:1-18. doi: 10.1080/15548627.2021.2016232. Epub ahead of print. PMID: 34964690.

Kins S, Schäfer KH, Endres K. Drug development for neurodegenerative diseases. Biol Chem. 2021 Nov 19;403(1):1. doi: 10.1515/hsz-2021-0413. PMID: 34791859.

Eggert S, Kins S, Endres K, Brigadski T. Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of Alzheimer's disease. Biol Chem. 2021 Oct 7;403(1):43-71. doi: 10.1515/hsz-2021-0330. PMID: 34619027.

Nguyen VTT, König S, Eggert S, Endres K, Kins S. The role of mycotoxins in neurodegenerative diseases: current state of the art and future perspectives of research. Biol Chem. 2021 Aug 27;403(1):3-26. doi: 10.1515/hsz-2021-0214. PMID: 34449171.

Kiss E, Kins S, Zöller Y, Schilling S, Gorgas K, Groß D, Schlicksupp A, Rosner R, Kirsch J, Kuhse J. Artesunate restores the levels of inhibitory synapse proteins and reduces amyloid-β and C-terminal fragments (CTFs) of the amyloid precursor protein in an AD-mouse model. Mol Cell Neurosci. 2021 Jun;113:103624. doi: 10.1016/j.mcn.2021.103624. Epub 2021 Apr 30. PMID: 33933588.

Augustin V, Kins S. Fe65: A Scaffolding Protein of Actin Regulators. Cells. 2021 Jun 25;10(7):1599. doi: 10.3390/cells10071599. PMID: 34202290; PMCID: PMC8304848.

Kiss E, Kins S, Gorgas K, Orlik M, Fischer C, Endres K, Schlicksupp A, Kirsch J, Kuhse J. Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABA_AR density. Biol Chem. 2021 Apr 20;403(1):73-87. doi: 10.1515/hsz-2021-0153. PMID: 33878252.

Eggert S,^* Grübl T,^*, Rupp C, Sander B, Heesch A, Rajender R, Zimmermann M, Höpfner S,Zentgraf H, Kins S (2020)The Rab5 activator RME-6 is required for Amyloid Precursor Protein (APP) endocytosis depending on the juxtamembranous YTSI motif, Cellular and Molecular Life Sciences volume 77, pages5223–5242

Kiss E, Groeneweg F, Gorgas K, Schlicksupp A, Kins S, Kirsch J, Kuhse J. (2020) Amyloid-β Fosters p35/CDK5 Signaling Contributing to Changes of Inhibitory Synapses in Early Stages of Cerebral Amyloidosis,J Alzheimers Dis. 2020;74(4):1167-1187. doi: 10.3233/JAD-190976

Delport A, Kins S, Hewer R (2020) The amyloid precursor protein affects glyceraldehyde 3-phosphate dehydrogenase levels, organelle localisation and thermal stability Molecular Biology Reports volume 47, pages3019–3024

Konietzko U, Gersbacher MT, Streuli J, Krüger M, Thöni S, KinsS, Nitsch RM. A fluorescent protein-readout for transcriptional activity reveals regulation of APP nuclear signaling by phosphorylation sites. Biol Chem. 2019 May 1. pii: /j/bchm.just-accepted/hsz-2019-0125/hsz-2019-0125.xml. doi: 10.1515/hsz-2019-0125. [Epub ahead of print]

Hermey G, Hoffmeister-Ullerich SA, Merz B, Groß D, Kuhl D, KinsS Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice. Biol Chem. 2019 May 16. pii: /j/bchm.ahead-of-print/hsz-2019-0146/hsz-2019-0146.xml. doi: 10.1515/hsz-2019-0146. [Epub ahead of print]

August A, Schmidt N, Klingler J, Baumkötter F, Lechner M, Klement J, Eggert S, Vargas C, Wild K, Keller S, Kins S. Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways. J Neurochem. 2019 May 7. doi: 10.1111/jnc.14716. [Epub ahead of print]

Hollnagel JO, Elzoheiry S, Gorgas K, Kins S, Beretta CA, Kirsch J, Kuhse J, Kann O, Kiss E (2019) Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer's disease amyloidosis. PLoS One 14:e0209228.

Eggert S, Thomas C, Kins S, Hermey G (2018) Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin. Mol Neurobiol 55: 5809-29.

Eggert S, Gonzalez AC, Thomas C, Schilling S, Schwarz SM, Tischer C, Adam V, Strecker P, Schmidt V, Willnow TE, Hermey G, Pietrzik CU, Koo EH, Kins S (2018) Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. Cell Mol Life Sci. 75: 301-22.

Feilen LP, Haubrich K, Strecker P, Probst S, Eggert S, Stier G, Sinning I, Konietzko U, Kins S, Simon B, Wild K (2017) Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction. Front Mol Neurosci 10:140.

Herr UM, Strecker P, Storck SE, Thomas C, Rabiej V, Junker A, Schilling S, Schmidt N, Dowds CM, Eggert S, Pietrzik CU, Kins S (2017) LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State. Front Mol Neurosci 10:118.

Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S*, Eggert S* (2017) APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. J Neurosci 37: 5345-5365. *contributed equally

Guénette S, Strecker P, Kins S (2017) APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins. Front Mol Neurosci 10:87.

Wild K, August A, Pietrzik CU, Kins S (2017) Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments. Front Mol Neurosci 10:21.

Kundu A, Milosch N, Antonietti P, Baumkötter F, Zymny A, Müller UC, Kins S, Hajieva P, Behl C, Kögel D (2016) Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP. Mol Neurobiol. 53: 5985-94

Strecker P, Ludewig S, Rust M, Mundinger TA, Görlich A, Krächan EG, Mehrfeld C, Herz J, Korte M, Guénette SY and Kins S (2016) FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation. Sci Reports 6: 25652

Kiss E, Gorgas K, Schlicksupp A, Groß D, Kins S, Kirsch J, Kuhse J (2016) Biphasic Alteration of the Inhibitory Synapse Scaffold Protein Gephyrin in Early and Late Stages of an Alzheimer Disease Model. Am J Pathol. S0002-9440: 30208-5

Morfini G, Schmidt N, Weissmann C, Pigino G, Kins S (2016) Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease.Brain Res Bull. 126: 347-353

Hermey G, Schmidt N, Bluhma B, Menschinga D, Ostermann K, Rupp C, Kuhl D and Kins S (2015) SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport, J Neurochem, 135:60-75

Renziehausen J, Hiebel C, Nagel H, Kundu A, Kins S, Kögel D, Behl C, Hajieva P (2015) The Cleavage Product of Amyloid-β Protein Precursor sAβPPα Modulates BAG3-Dependent Aggresome Formation and Enhances Cellular Proteasomal Activity. J Alzheimers Dis. 44: 879-96

Stahl R, Schilling S, Soba P, Rupp C, Hartmann T, Wagner K, Merdes G, Eggert S and Kins S (2014) Shedding of APP limits its synaptogenic activity and cell adhesion properties. Front Cell Neurosci 8: e410

Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW, Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D. (2014) Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway.Cell Death Dis, 5: e1391

Rupp C, Beyreuther K, Maurer K and Kins S (2014) A presenillin1 mutation in the first case of Alzheimer’s disease: revisited. Alzheimers Dement, 10: 869-72

Baumkötter F, Schmidt N, Vargas C, Schilling S, Weber R, Wagner K, Fiedler S, Klug W, Radzimanowski J, Nickolaus S, Keller S, Eggert S, Wild K and Kins S (2014) Amyloid Precursor Protein dimerization and synaptogenic function depend on copper binding to the growth factor like domain. J Neurosci 34: 11159-72

Klevanski M, Saar M, Baumkötter F, Weyer SW, Kins S, Müller UC. (2014) Differential role of APP and APLPs for neuromuscular synaptic morphology and function. Mol Cell Neurosci 61: 201-10

Thyrock A, Ossendorf E, Stehling M, Kail M, Kurtz T, Pohlentz G, Waschbüsch D, Eggert S, Formstecher E, Müthing J, Dreisewerd K, Kins S, Goud B, Barnekow A (2013) A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. PLoS One 8: e64149

Riemer J, Kins S. (2013) Axonal Transport and Mitochondrial Dysfunction in Alzheimer's Disease.Neurodegener Dis 12: 111-24

Grimm MO, Rothhaar TL, Grösgen S, Burg VK, Hundsdörfer B, Haupenthal VJ, Friess P, Kins S, Grimm HS, Hartmann T (2012) Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP).J Nutr Biochem 23: 1214-23

Isbert S, Wagner K, Eggert S, Schweitzer A, Multhaup G, Weggen S, Kins S, Pietrzik CU (2012) APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms.Cell Mol Life Sci 69: 1353-75

Brunholz S, Sisodia S, Lorenzo A, Deyts C, Kins S, Morfini G (2012) Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells.Exp Brain Res 217: 353-64

Baumkötter F, Wagner K, Eggert S, Wild K, Kins S (2012) Structural aspects and physiological consequences of APP/APLP trans-dimerization.Exp Brain Res 217: 389-95

Szodorai A, Kuan YH, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S (2009) APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. J Neurosci 29: 14534-14544.

DeBoer S, You Y, Szodorai S, Kaminska A, Pigino G, Nwabuisi E, Estrada-Hernandez T, Kins S, Brady ST and Morfini G (2008) Conventional Kinesin is Composed of Kinesin Heavy and Light Chain homodimers. Biochemistry 47: 4535-43.

Kins S and Beyreuther K (2008) Alzheimer’s Disease. In: „Encyclopedia of Molecular Mechanisms of Disease“, Springer Verlag.

Back S, Haas P, Tschäpe JA, Gruebl T, Kirsch J, Müller U, Beyreuther K, Kins S (2007) In neurons APP can be transported independent of any sorting signal to the axonal and dendritic compartment. J Neurosci Res 25: 1079-86

Rusu P, Jansen A, Soba P, Kirsch J, Löwer A, Merdes G, Kuan Y-H, Jung A, Beyreuther K, Kjaerulff O, Kins S (2007) Axonopathy in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity, Eur J Neurosci 25: 1079-86

Kuan Y-H, Grübl T, Soba P, Eggert S, Nesic I, Kirsch J, Beyreuther K, KinsS (2006) The processing and anterograde transport of APP, APLP1 and APLP2 is affected by the carboxyl-terminal binding partner PAT1a. J Biol Chem 281: 40114-123.

KinsS, Lauther N, Szodorai A, and Beyreuther K (2006) Subcellular trafficking of the APP gene family and its pathogenic role in Alzheimer’s Disease. Neurodegener Dis 3: 218-26.

Kins S, Beyreuther K (2006) Teasing out the tangles. Nature Med 12: 764-5.

Götz J, Ittner LM, and Kins, S (2006) Do axonal defects in tau and APP transgenic animals model axonopathy in Alzheimer’s disease? J Neurochem 98: 993-1006.

Horster F, Schwab MA, Sauer SW, Pietz J, Hoffmann GF, Okun JG, Kolker S, Kins S (2006) Phenylalanine reduces synaptic density in mixed cortical cultures from mice. Pediatr Res 59: 544-48.

Soba P, Eggert S, Zentgraf H, Kreger S, Löwer A, Merdes G, Paro R, Masters CL, Müller U, Kins S*, Beyreuther K* (2005) Cell interactions are promoted by trans-dimerization of APP family members, arranged as homo- or hetero-complexes in synaptic membranes. EMBO J 24: 3624-36. *These two authors contributed equally

von Rotz RC, Kins S, Hipfel R, von der Kammer H, Nitsch RM (2005) The cytosolic ring finger protein dactylidin is selectively upregulated in brains of patients with Alzheimer’s disease. Eur J Neurosci 21: 1289-98.

Lazarov O, Morfini GA, Szodorai A, Kins S, Lee V, Trojanowski J, Price D, Brady ST, Sisodia SS (2005) Axonal Transport, APP, Kinesin and the Processing Apparatus: Revisited. J Neurosci 25: 2386-95.

KinsS, Kurosinski P, Nitsch RM and Götz J (2003) Hyperphosphorylation and somatodendritic localization of tau in PP2A dominant negative mutant mice is associated with activation of ERK and JNK signaling. J Am Path 163: 833-843.

Chen F, Ferrari A, Schild A, Kurosinski P, David D, Hoerndli F, Pennanen L, Kins S, van Dorpe J, Nitsch RM, Götz J (2003) Amyloid-induced neurofibrillary tangle formation. In: Alzheimer‚s disease and related disorders: Research advances (editors: K. Iqbal, B. Winblad; Ana Aslan International Foundation)

Schmidt K, KinsS, Schild A, Nitsch RM, Hemmings B and Gotz J (2002) Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A. Eur J Neurosci 16: 2039-48.

Fuhrmann JC, KinsS, Kirsch J, Kneussel M, Betz H (2002) Gephyrin interacts with DLC-1/PIN and DLC-2, components of the cytoplasmic dynein complex. J Neurosci 22: 5393-402.

Müller U and Kins S (2002) APP on the move. Trends Mol Med. 8: 152-5.

Steinhoff T, Moritz E, Wollmer MA, Mohajeri MH, KinsS and Nitsch RM (2001) Increased cystatin C in astrocytes of transgenic mice expressing the K670N-M671L mutation of the amyloid precursor protein and deposition in brain amyloid plaques. Neurobiol Dis 8: 647-54.

Kins S, Crameri A, Evans DR, Hemmings BA, Nitsch RM, and Gotz J (2001) Reduced PP2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. J Biol Chem 276: 38193-200.

Grosskreutz Y, Hermann A, KinsS, Fuhrmann JC, Betz H, and Kneussel M (2000) Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin. Biol Chem  382: 1455-62.

Ramming M, KinsS, Werner N, Hermann A, Betz H, and Kirsch J (2000) Diversity and phylogeny of gephyrin: tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteins. Proc Natl Acad Sci U S A 97: 10266-71.

Kins S, Betz H, and Kirsch J (2000) Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin. Nature Neurosci 3: 22-29.

Kins S, Kuhse J, Laube B, Betz H and Kirsch J (1999) Incorporation of a gephyrin-binding motif targets NMDA receptors to gephyrin-rich domains in HEK 293 cells. Eur J Neurosci 11: 740-4